Description
Technical Parameters
Basic Information
- Chemical name: Lithium dodecyl sulfate
- Type: Anionic surfactant
- Structure: Dodecyl (C12) hydrophobic chain + sulfate head group
- Similar to: Sodium dodecyl sulfate (SDS)
- Key advantage: Better solubility and stability at lower temperatures compared to SDS
Main Applications
1. Denaturing Polyacrylamide Gel Electrophoresis (PAGE)
LDS is commonly used in denaturing PAGE, especially as an alternative to SDS in protein electrophoresis systems.
Why LDS is preferred in some systems:
- Maintains better solubility at low temperatures
- Reduces precipitation problems sometimes seen with SDS
- Efficiently denatures proteins by:
Disrupting non-covalent bonds
Coating proteins with uniform negative charge
Allowing separation based on molecular weight
LDS buffer systems are often used in modern precast gel electrophoresis kits for improved protein resolution.
2. Pharmaceutical Applications
- Pharmaceutical dispersant: Helps disperse poorly soluble active ingredients.
- Biopharmaceutical equipment cleaning: Effective in removing protein residues from stainless steel and laboratory equipment.
- Fine instrument cleaning: Suitable for sensitive laboratory systems.
3. Laboratory & Industrial Uses
- Electrophoresis reagent
- Desiccant/preservative systems (support role)
- Protein solubilization
- Surface cleaning agent in biotech facilities
Advantages of Lithium Dodecyl Sulfate
- Strong protein denaturing capability
- Excellent solubilizing power
- Improved low-temperature performance
- High purity grades available for research use
- Suitable for pharmaceutical and biotech environments
Specs
|
INDEX VALUE NAME OF INDEX |
Reagent grade |
||
|
99% grade |
97% grade |
||
|
Appearance |
White flake crystal |
White powder |
|
|
Active matter %≥ |
99.5 |
97 |
|
|
PH (1% water solution) |
6.0-9.0 |
7.5-10.5 |
|
|
Fraction content % ≥ |
99.5 |
99.5 |
|
|
Light absorption value (3%, deionized water) |
230nm,≤ |
0.4 |
- |
|
260nm,≤ |
0.1 |
- |
|
|
280nm,≤ |
0.075 |
- |
|
|
410nm,≤ |
0.01 |
- |
|
